2093946-08-6
中文名稱
化合物 YQ456
英文名稱
Benzamide, 3-[3-ethyl-5-(4-methoxyphenyl)-1H-1,2,4-triazol-1-yl]-N-(4-phenylbutyl)-
CAS
2093946-08-6
分子式
C28H30N4O2
分子量
454.56
MOL 文件
2093946-08-6.mol
2093946-08-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 YQ456 英文別名
Benzamide, 3-[3-ethyl-5-(4-methoxyphenyl)-1H-1,2,4-triazol-1-yl]-N-(4-phenylbutyl)-物理化學(xué)性質(zhì)
密度1.14±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)14.20±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
YQ456 is a novel potent and selective inhibitor of myoferlin (MYOF inhibitor), which attenuates colorectal cancer progression. YQ456 showed high binding affinity to MYOF (KD = 37 nM) and excellent anti-invasion capability (IC50 = 110 nM). YQ456 was reported for the first time to interfere with the interactions between MYOF and Ras-associated binding (Rab) proteins at low nanomolar levels. This interference disrupted several vesicle trafficking processes, including lysosomal degradation, exosome secretion, and mitochondrial dynamics. Further, YQ456 exhibited excellent inhibitory effects on the growth and invasiveness of colorectal cancer. As the first attempt, the anticancer efficacy of YQ456 in the patient-derived xenograft (PDX) mouse model indicated that targeting MYOF may serve as a novel and practical therapeutic approach for colorectal cancer.