2101208-44-8
中文名稱
化合物 T23902
英文名稱
CM03
(G-quadruplex binder CM03)
CAS
2101208-44-8
分子式
C34H44N6O6
分子量
632.75
MOL 文件
2101208-44-8.mol
2101208-44-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點822.4±65.0 °C(Predicted)
密度1.321±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)9.86±0.20(Predicted)
形態(tài)Solid
顏色Brown to dark brown
應(yīng)用領(lǐng)域
用途一
CM03 is a potent inhibitor of cell growth in PDAC cell lines, and has anticancer activity in PDAC models, with a superior profile compared to gemcitabine, a commonly used therapy. Whole-transcriptome RNA-seq methodology has been used to analyze the effects of this quadruplexbinding small molecule on global gene expression. This has revealed the down-regulation of a large number of genes, rich in putative quadruplex elements and involved in essential pathways of PDAC survival, metastasis, and drug resistance. The changes produced by CM03 represent a global response to the complexity of human PDAC and may be applicable to other currently hard-to-treat cancers.