2102672-22-8
2102672-22-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)417.7±45.0 °C(Predicted)
密度1.611±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 83.33 mg/mL (204.39 mM)
酸度系數(shù)(pKa)7.22±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.常見問題列表
概述
DK419 是一種有效、可口服的 Wnt/β-catenin 信號通路抑制劑，IC50 值為 0.19 μM。DK419 能降低 Axin2，β-catenin，c-Myc，Cyclin D1 和 Survivin 能夠改變細(xì)胞內(nèi)耗氧率，誘導(dǎo) pAMPK 的產(chǎn)生。