2123484-71-7
中文名稱
(±)10(11)-EDP ETHANOLAMIDE
英文名稱
10,11-EDP epoxide
CAS
2123484-71-7
分子式
C24H37NO3
分子量
387.56
MOL 文件
2123484-71-7.mol
2123484-71-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
應(yīng)用領(lǐng)域
用途一
(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; ) by cytochrome P450 (CYP) epoxygenases. 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay.