21306-65-0

中文名稱 S-[4-(芐氧基)苯基]-S-甲基-N-(對(duì)甲苯基磺酰基)-硫亞胺

英文名稱 NPD-123

CAS 21306-65-0

分子式 C21H21NO3S2

分子量 399.53

MOL 文件 21306-65-0.mol

更新日期 2024/12/05 21:11:28

21306-65-0 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) S-[4-(芐氧基)苯基]-S-甲基-N-(對(duì)甲苯基磺?；?-硫亞胺價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

S-[4-(芐氧基)苯基]-S-甲基-N-(對(duì)甲苯基磺?；?-硫亞胺

英文別名

TPh A
NPD-123
Triphenyl compound A
S-Methyl-S-(4-benzyloxy-phenyl)-N-(p-toluolsulfonyl)-sulfimid
S-[4-(Benzyloxy)phenyl]-S-methyl-N-(p-tolylsulfonyl)-sulfilimine
S-[p-(Benzyloxy)phenyl]-S-methyl-N-(p-tolylsulfonyl)-sulfilimine
N-{[4-(Benzyloxy)phenyl](methyl)-γ4-sulfanylidene}-4-methylbenzenesulfonamide
Benzenesulfonamide, 4-methyl-N-[methyl[4-(phenylmethoxy)phenyl]-λ4-sulfanylidene]-

物理化學(xué)性質(zhì)

沸點(diǎn)587.6±60.0 °C(Predicted)

密度1.22±0.1 g/cm3(Predicted)

儲(chǔ)存條件2-8°C

溶解度二甲基亞砜：>30mg/mL

形態(tài)白色粉末

顏色白色

InChI1S/C21H21NO3S2/c1-17-8-14-21(15-9-17)27(23,24)22-26(2)20-12-10-19(11-13-20)25-16-18-6-4-3-5-7-18/h3-15H,16H2,1-2H3

InChIKeyIMUPOWQOXOCVBN-UHFFFAOYSA-N

SMILESCc1ccc(cc1)S(=O)(=O)N=S(C)c2ccc(OCc3ccccc3)cc2

安全數(shù)據(jù)

WGK Germany3

存儲(chǔ)類別11 - Combustible Solids

S-[4-(芐氧基)苯基]-S-甲基-N-(對(duì)甲苯基磺?；?-硫亞胺價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-14454	S-[4-(芐氧基)苯基]-S-甲基-N-(對(duì)甲苯基磺酰基)-硫亞胺 TPh A	21306-65-0	5mg	1000元
2026/06/05	HY-14454	S-[4-(芐氧基)苯基]-S-甲基-N-(對(duì)甲苯基磺?；?-硫亞胺 TPh A	21306-65-0	10 mM * 1 mLin DMSO	1100元
2026/06/05	HY-14454	S-[4-(芐氧基)苯基]-S-甲基-N-(對(duì)甲苯基磺?；?-硫亞胺 TPh A	21306-65-0	10mg	1700元

常見(jiàn)問(wèn)題列表

生物活性

TPh A (Triphenyl Compound A) 是核蛋白 pirin 的有效抑制劑，其 Ki 值為0.6 uM。TPh A 破壞 Bcl3-pirin 復(fù)合物的形成。TPh A 可作為相關(guān)的小分子工具調(diào)控細(xì)胞內(nèi)的 Pirin。

體外研究

The Pirin is a nuclear protein with the nuclear factor I/CCAAT box transcription factor (NFI/CTF). Pirin proteins are highly conserved between mammals, plants, fungi, and prokaryotic organisms and are considered to belong to the cupin superfamily.TPh A (20 μM; 5 hours) reduces the amount of pirin-bound Bcl3 and inhibits the interaction between pirin and Bcl3 in HEK293T cells in a glutathione S-transferase (GST) pulldown assay (HEK293T cells are transfected with vectors that encoded bcl3-Myc and pirin-His6 for 43 h of transfection).TPh A (0-100 μM; 48 hours) does not exert any potent cytotoxic activity against many human cancer cell lines, it against MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells with IC ₅₀ values >50 μM, and exhibits IC ₅₀ values of 27 μM, 20 μM and 26 μM for PC3 HL60 and HT29 cells, respectively.TPhA (0-50 μM; 48 hours) inhibits cell migration in WM266-4 cells, SK-MEL-28 cell in a concentration-dependent manner.

Cell Viability Assay

Cell Line:	MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells
Concentration:	0-100 μM
Incubation Time:	48 hours
Result:	Did not exert any potent cytotoxic activity against many human cancer cell lines.