2138300-40-8

中文名稱 STING AGONIST-4

英文名稱 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

CAS 2138300-40-8

分子式 C34H38N12O4

分子量 678.74

MOL 文件 2138300-40-8.mol

更新日期 2023/03/20 15:41:23

2138300-40-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 圖譜信息 STING AGONIST-4價(jià)格(試劑級) 常見問題列表

基本信息

中文別名

化合物STING AGONIST-4

英文別名

STING agonist-4
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

所屬類別

生物化工：生化試劑

物理化學(xué)性質(zhì)

密度1.48±0.1 g/cm3(Predicted)

儲(chǔ)存條件-20°C儲(chǔ)存

溶解度DMSO: slightly soluble

酸度系數(shù)(pKa)11.97±0.43(Predicted)

形態(tài)固體

顏色White to gray

InChIKeyICZSAXDKFXTSGL-UHFFFAOYSA-N

SMILESC(N1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21)CCCN1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21

圖譜信息

STING AGONIST-4(2138300-40-8)核磁圖(¹HNMR)

STING AGONIST-4價(jià)格(試劑級)

報(bào)價(jià)日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價(jià)格
2026/06/05	HY-123943	STING agonist-4	2138300-40-8	1 mg	1600元
2026/06/05	HY-123943	STING AGONIST-4 STING agonist-4	2138300-40-8	5mg	3500元
2026/06/05	HY-123943	STING AGONIST-4 STING agonist-4	2138300-40-8	10mg	5000元

常見問題列表

生物活性

STING agonist-4 是干擾素基因 (STING) 的受體激動(dòng)劑的刺激劑，它的表觀抑制常數(shù) IC50 為 20 nM，STING agonist-4 是一種含兩個(gè)對稱相關(guān)的氨基苯并咪唑 (ABZI) 基的化合物。

靶點(diǎn)

IC50: 20 nM (STING agonist-4)

體外研究

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC ₅₀ of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K _d ) of approximately 1.6 nM. STING agonist-4 (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC ₅₀ of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.

Cell Viability Assay