2154350-81-7
英文名稱
2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
CAS
2154350-81-7
分子式
C46H49ClN10O3
分子量
825.4
MOL 文件
2154350-81-7.mol
2154350-81-7 結(jié)構(gòu)式
基本信息
英文別名
CFT-7432,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
應(yīng)用領(lǐng)域
用途一
CFT-743 is a potent BET degrader. In vitro, CFT-743 is more potent than a BET inhibitor (AZD5153) and a CDK9 inhibitor (dinaciclib) in 100% and 97% of 38 leukemia lines tested. In mice bearing HL60 tumors, CFT-743 has similar efficacy as dinaciclib (81% regression versus 99% tumor growth inhibition (TGI)).