215804-67-4
215804-67-4 結構式
基本信息
SB-277011-A鹽酸鹽水合物
化合物 SB-277011 HYDROCHLORIDE
SB 277211 Hydrochloride
SB 277011A Hydrochloride
SB-277011-A hydrochloride hydrate
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]- 4-quinolinecarboxaMide Hydrochloride
物理化學性質
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-10847B | 化合物 SB-277011 HYDROCHLORIDE SB-277011 hydrochloride | 215804-67-4 | 5mg | 1000元 |
| 2026/06/05 | HY-10847B | 化合物 SB-277011 HYDROCHLORIDE SB-277011 hydrochloride | 215804-67-4 | 10mM * 1mLin DMSO | 1045元 |
| 2026/06/05 | HY-10847B | 化合物 SB-277011 HYDROCHLORIDE SB-277011 hydrochloride | 215804-67-4 | 10mg | 1600元 |
常見問題列表
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D 3 Receptor 10.7-11.2 nM (Ki) |
D 2 Receptor
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5-HT 1D Receptor
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5-HT 1B Receptor
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SB-277011 hydrochloride has an excellent pharmacokinetic profile, exhibits oral bioavailability 43%, half-life:2.0 h, plasma clearance 19 mL/min/kg) and to be highly brain-penetrant (brain:blood ratio of 3.6:1), with a clean P450 profile in the rat.SB-277011 hydrochloride (SB 277011; 3 mg/kg, p.o.) completely reverses the effects of quinelorane in the nucleus accumbens, but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats.SB-277011 (intraperitoneal injection; 12.5-25 mg/kg) significantly and dose-dependently reduces intravenous cocaine self-administration under both low fixed-ratio and progressive-ratio reinforcement conditions in rats. When it increases to 50 mg/kg, SB-277011 can significantly inhibit basal and cocaine-enhanced locomotion in rats.