2162961-71-7
2162961-71-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)668.9±55.0 °C(Predicted)
密度1.513±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (474.01 mM)
酸度系數(shù)(pKa)7.46±0.40(Predicted)
形態(tài)固體
顏色Off-white to light yellow
InChIKeyZDOBSAPHUUUOHX-OSYLJGHBSA-N
SMILESO=C(N1C[C@]2([H])[C@@H](CNC(C3=CC=C(NN=N4)C4=C3)=O)[C@]2([H])C1)OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5
BI-2545價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-124772 | BI-2545 BI-2545 | 2162961-71-7 | 5mg | 950元 |
| 2026/06/05 | HY-124772 | BI-2545 BI-2545 | 2162961-71-7 | 10mM * 1mLin DMSO | 1102元 |
| 2026/06/05 | HY-124772 | BI-2545 BI-2545 | 2162961-71-7 | 10mg | 1400元 |
常見(jiàn)問(wèn)題列表
生物活性
BI-2545 是一種高效的 autotaxin (ATX) 抑制劑，可顯著降低 LPA 的水平，對(duì)人和大鼠的 ATX 作用 IC50 值分別為 2.2 nM 和3.4 nM。靶點(diǎn)
C50: 2.2 nM (human ATX), 3.4 nM (rat ATX)
體外研究
BI-2545 displays good potency in the LPA and rat whole blood assay with IC
50
s of 29 nM and 96 nM, respectively.
體內(nèi)研究
BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs.
BI-2545 (10 mg/kg; p.o.) has a half-life of t
1/2
=3.4 hours.
| Animal Model: | Rat |
| Dosage: | 10 mg/kg |
| Administration: | Oral administration |
| Result: | Reduces the sum of the plasma LPA species up to 90%. |