2169905-68-2
中文名稱
化合物 VEMTOBERANT
英文名稱
4(1H)-Quinolinone, 1-ethyl-3-[[(3R)-3-[[(2S)-2-hydroxy-3-[3-(methylsulfonyl)phenoxy]propyl]amino]-1-oxa-8-azaspiro[4.5]dec-8-yl]sulfonyl]-
CAS
2169905-68-2
分子式
C29H37N3O8S2
分子量
619.75
MOL 文件
2169905-68-2.mol
2169905-68-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 VEMTOBERANT 英文別名
4(1H)-Quinolinone, 1-ethyl-3-[[(3R)-3-[[(2S)-2-hydroxy-3-[3-(methylsulfonyl)phenoxy]propyl]amino]-1-oxa-8-azaspiro[4.5]dec-8-yl]sulfonyl]-物理化學(xué)性質(zhì)
沸點(diǎn)851.6±75.0 °C(Predicted)
密度1.44±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13.70±0.20(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
應(yīng)用領(lǐng)域
用途一
Vemtoberant, also known as APD418, is a β3-adrenergic receptor (AdrR) antagonist for treatment of decompensated heart failure. Unlike current inotrope therapie , Vemtoberant improves cardiac contractility with minimal negative impact on heart rate, blood pressure, and myocardial oxygen consumption. Vemtoberant has undergone Phase 2 trials for those in heart failure with reduced ejection fraction.