219757-90-1
中文名稱
219757-90-1
英文名稱
SULAMSEROD
CAS
219757-90-1
分子式
C19H28ClN3O5S
分子量
445.96
MOL 文件
219757-90-1.mol
219757-90-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13021 英文別名
RS-100302SULAMSEROD
Methanesulfonamide, N-[2-[4-[3-(8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-oxopropyl]-1-piperidinyl]ethyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)647.8±65.0 °C(Predicted)
密度1.319±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.22±0.40(Predicted)
常見問(wèn)題列表
生物活性
Sulamserod 是一種 5-HT4 receptor 拮抗劑，具有抗心律失常的功效。靶點(diǎn)
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5-HT 4 Receptor
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體內(nèi)研究
Sulamserod (30 mg/kg) prolongs mean ERP (11568 versus 14667 ms, P,0.01) and wavelength (8.360.9 versus 9.960.8 cm, P,0.01), reduces dispersion of ERP (1565 versus 861 ms, P,0.01), and minimally slows conduction velocity (7264 versus 6765 cm/s, P,0.01) in pigs. Sulamserod produces no ventricular electrophysiological effects. Sulamserod terminates atrial flutter in 6 of 8 animals and atrial fibrillation in 8 of 9 animals and prevents reinduction of sustained tachycardia in all animals.