2215852-91-6
中文名稱(chēng)
GSK3395879
英文名稱(chēng)
GSK3395879
CAS
2215852-91-6
分子式
C20H15F4N3O5S
分子量
485.41
MOL 文件
2215852-91-6.mol
2215852-91-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)665.8±65.0 °C(Predicted)
密度1?+-.0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.57±0.40(Predicted)
應(yīng)用領(lǐng)域
用途一
GSK3395879 is a potent, selective and orally active TRPV4 inhibitor (IC50 = 1 nM), GSK3395879 demonstrated the ability to inhibit TRPV4-mediated pulmonary edema in an in vivo rat model. GSK3395879 is a tool for studying the biology of TRPV4 and an advanced lead for identifying new heart failure medicines.