222631-44-9
222631-44-9 結(jié)構(gòu)式
基本信息
(2S,3S,4R,5R)-2-(4-氨基-5H-吡咯并[3,2-D]嘧啶-7-基)-5-(羥基甲基)-3,4-吡咯烷二醇單鹽酸鹽
Galidesivir)
Galidesivir HCl
BCX-4430 (BCX4430
BCX4430
GALIDESIVIR
BCX 4430 hydrochloride
Galidesivir hydrochloride
Immucillin-A hydrochloride
GALIDESIVIR HYDROCHLORIDE (BCX 4430 HYDROCHLORIDE)
(2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol monohydrochloride
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-18649 | (2S,3S,4R,5R)-2-(4-氨基-5H-吡咯并[3,2-D]嘧啶-7-基)-5-(羥基甲基)-3,4-吡咯烷二醇單鹽酸鹽 Galidesivir hydrochloride | 222631-44-9 | 1mg | 1600元 |
| 2026/06/05 | HY-18649 | (2S,3S,4R,5R)-2-(4-氨基-5H-吡咯并[3,2-D]嘧啶-7-基)-5-(羥基甲基)-3,4-吡咯烷二醇單鹽酸鹽 Galidesivir hydrochloride | 222631-44-9 | 5mg | 4800元 |
| 2026/06/05 | HY-18649 | (2S,3S,4R,5R)-2-(4-氨基-5H-吡咯并[3,2-D]嘧啶-7-基)-5-(羥基甲基)-3,4-吡咯烷二醇單鹽酸鹽 Galidesivir hydrochloride | 222631-44-9 | 10 mM * 1 mLin DMSO | 5280元 |
常見問題列表
RdRp inhibitor
Cellular kinases phosphorylate Galidesivir (BCX4430) hydrochloride to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination.
Galidesivir hydrochloride effectively inhibits the infection of Vero cells with YFV. The EC
50
determined by the neutral red uptake assay is 8.3 μg/ml (24.5 μM).
Galidesivir (BCX4430) hydrochloride is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir hydrochloride has demonstrated pronounced efficacy.
Galidesivir hydrochloride (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF).
| Animal Model: | Female Syrian golden hamsters (hamsters infected with YF virus) |
| Dosage: | 4 mg/kg of body weight |
| Administration: | I.p.; twice daily for 7 days |
| Result: | Significantly improved the survival of hamsters infected with YFV. |