2230821-68-6
中文名稱
SJF-8240
英文名稱
Foretinib-Based PROTAC 7
CAS
2230821-68-6
分子式
C58H65F2N7O11S
分子量
1106.25
MOL 文件
2230821-68-6.mol
2230821-68-6 結(jié)構(gòu)式
基本信息
中文別名
SJF 8240,C-MET降解劑 英文別名
Foretinib-Based PROTAC 71-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
物理化學(xué)性質(zhì)
沸點1226.5±65.0 °C(Predicted)
密度1.341±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO|55.31|50|
酸度系數(shù)(pKa)13.14±0.70(Predicted)
形態(tài)Solid
顏色White to light yellow
應(yīng)用領(lǐng)域
用途一
SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells.