2231747-03-6
2231747-03-6 結構式
物理化學性質
沸點550.4±50.0 °C(Predicted)
密度1.273±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: ≥ 250 mg/mL (843.68 mM)
酸度系數(shù)(pKa)9.09±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
InChIKeyRFDVEAHRRMEOHK-UHFFFAOYSA-N
SMILESCC1=NOC(C)=C1C2=CC(C(O)C3=CN=CC=C3)=CC(O)=C2
OXFBD04價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-135236 | OXFBD04 | 2231747-03-6 | 1 mg | 572元 |
| 2025/12/22 | HY-135236 | OXFBD04 OXFBD04 | 2231747-03-6 | 5mg | 1420元 |
| 2025/12/22 | HY-135236 | OXFBD04 OXFBD04 | 2231747-03-6 | 10mM * 1mLin DMSO | 1864元 |
常見問題列表
生物活性
OXFBD04 是一種有效的選擇性 BRD4 抑制劑，IC50 為 166 nM。OXFBD04 是一種有效的 BET 溴結構域配體，對 CREBBP 溴結構域具有額外的適度親和力。OXFBD04 具有抗癌活性。靶點
|
BRD4 166 nM (IC 50 ) |
體外研究
OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth.
OXFBD04 (10?μM; for 10, 24, or 48?hours) induces MYC suppression in MCF7 breast cancer cells.
Cell Viability Assay
| Cell Line: | A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines |
| Concentration: | 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cancer cell lines growth. |
體內研究
OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t
1/2
=388?min). OXFBD04 has CL
int
of 3.57 μL/min/mg.