2234271-86-2
2234271-86-2 結構式
基本信息
中文別名
化合物JI130 英文別名
JI-130)JI130 (JI 130
2-Propenamide, 3-(7-methoxy-1H-indol-3-yl)-N-[2-[2-(2-propen-1-yloxy)phenyl]ethyl]-, (2E)-
物理化學性質
儲存條件2-8°C
溶解度DMSO: 2mg/mL, clear
形態(tài)Solid
顏色White to light yellow
InChI1S/C23H24N2O3/c1-3-15-28-20-9-5-4-7-17(20)13-14-24-22(26)12-11-18-16-25-23-19(18)8-6-10-21(23)27-2/h3-12,16,25H,1,13-15H2,2H3,(H,24,26)/b12-11+
InChIKeyBNTYDBBGNPFECO-VAWYXSNFSA-N
SMILESO=C(/C=C/C1=CNC2=C1C=CC=C2OC)NCCC3=CC=CC=C3OCC=C
應用領域
用途一
JI130 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. JI130 stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest.