22350-90-9
中文名稱
指孢菌素
英文名稱
(2S,3R)-1,2,3,4-Tetrahydro-2,3,5-trihydroxy-7-methoxy-2-methyl-9,10-anthracenedione
CAS
22350-90-9
分子式
C16H16O6
分子量
304.29
MOL 文件
22350-90-9.mol
22350-90-9 結(jié)構(gòu)式
基本信息
中文別名
指孢菌素化合物 T23953
英文別名
Altersolanol B(2S)-1,2,3,4-Tetrahydro-2α,3α,5-trihydroxy-7-methoxy-2-methyl-9,10-anthracenedione
(2S,3R)-1,2,3,4-Tetrahydro-2,3,5-trihydroxy-7-methoxy-2-methyl-9,10-anthracenedione
9,10-Anthracenedione, 1,2,3,4-tetrahydro-2,3,5-trihydroxy-7-methoxy-2-methyl-, (2S,3R)-
應(yīng)用領(lǐng)域
用途一
Dactylarin is cytotoxic antibiotic. Dactylarin isolated from Dactylaria lutea (Deuteromycetes). Cytotoxic effect of dactylarin on Ehrlich ascites carcinoma cells is caused by the inhibition of some SH-dependent glycolytic enzymes, especially of hexokinase (EC 2.7.1.1), glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) and 6-phosphofructokinase (EC 2.7.1.11). Dactylarin interacts with thiols, which explains its inhibitory effectiveness on the above glycolytic enzymes.