2235394-90-6
2235394-90-6 結構式
基本信息
中文別名
6-[(3S,4S)-4-氨基-3-甲基-2-氧雜-8-氮雜螺[4.5]癸烷-8-基]-3-[3-氯-2-(環(huán)丙基氨基)-4-吡啶基]-5-甲基-2H-吡唑并[3,4-D]嘧啶-4(5H)-酮 英文別名
SHP389物理化學性質(zhì)
沸點733.1±70.0 °C(Predicted)
密度1.67±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)6.87±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
應用領域
用途一
SHP389 is an allosteric SHP2 Inhibitor with (SHP2 IC50 - 36 nM). SHP389 modulates MAPK signaling in vivo.SHP389 improved SHP2 biochemical and cellular potency in trend with increasing lipophilicity.