22550-15-8
中文名稱
異隱丹參酮
英文名稱
(8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
CAS
22550-15-8
分子式
C19H20O3
分子量
296.36
MOL 文件
22550-15-8.mol
更新日期
2023/08/07 15:35:42
22550-15-8 結(jié)構(gòu)式
基本信息
中文別名
異隱丹參酮異丹參酮 III
英文別名
Isotanshinone IIIIsocryptotanshinone
(+)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
(8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
Phenanthro[3,2-b]furan-7,11-dione, 1,2,3,4,8,9-hexahydro-4,4,8-trimethyl-, (8S)-
所屬類別
有機(jī)原料：酮類化合物物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形態(tài)粉末
常見問(wèn)題列表
生物活性
Isocryptotanshinone 是一種有效的信號(hào)傳導(dǎo)與轉(zhuǎn)錄激活因子3 (STAT3) 和蛋白酪氨酸磷酸酶1 B (PTP1B) 的抑制劑，其對(duì) PTP1B 的 IC50 值為 56.1 μM。靶點(diǎn)
|
STAT3
|
PTP1B 56.1 μM (IC 50 ) |
體外研究
It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner.