2270879-17-7
分子量
318.27
更新日期
2026/07/22 12:56:47
基本信息
英文別名
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)ureaUrea, N-[3-(difluoromethyl)-5-isothiazolyl]-N'-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]-
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于DMSO
酸度系數(shù)(pKa)11.76±0.70(Predicted)
形態(tài)固體
顏色White to off-white
InChI1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
InChIKeyCKYCAIAVJIFWPE-UHFFFAOYSA-N
SMILESO=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2
常見問題列表
概述
BRM/BRG1 ATP Inhibitor-1 (compound 14) 是一種具有口服活性的變構(gòu) brahma 同系物 (BRM)/SMARCA2 (SWI/SNF 相關(guān)的染色質(zhì)亞家族成員 2 的基質(zhì)相關(guān)肌動(dòng)蛋白依賴調(diào)節(jié)因子) 和 brahma 相關(guān)基因 1 (BRG1)/SMARCA4 三磷酸腺苷酶活性雙抑制劑，IC50 值均低于 0.005 μM。BRM/BRG1 ATP Inhibitor-1 具有抗癌活性。1-(3-(DIFLUOROMETHYL)ISOTHIAZOL-5-YL)-3-(2-FLUORO-5-(HYDROXYMETHYL)PYRIDIN-4-YL)UREA價(jià)格(試劑級(jí))
1-(3-(DIFLUOROMETHYL)ISOTHIAZOL-5-YL)-3-(2-FLUORO-5-(HYDROXYMETHYL)PYRIDIN-4-YL)UREA價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-119374 | 1-(3-(DIFLUOROMETHYL)ISOTHIAZOL-5-YL)-3-(2-FLUORO-5-(HYDROXYMETHYL)PYRIDIN-4-YL)UREA BRM/BRG1 ATP Inhibitor-1 | 2270879-17-7 | 1 mg | 2000元 |
| 2026/06/05 | HY-119374 | 1-(3-(DIFLUOROMETHYL)ISOTHIAZOL-5-YL)-3-(2-FLUORO-5-(HYDROXYMETHYL)PYRIDIN-4-YL)UREA BRM/BRG1 ATP Inhibitor-1 | 2270879-17-7 | 5 mg | 3600元 |
| 2026/06/05 | HY-119374 | 1-(3-(DIFLUOROMETHYL)ISOTHIAZOL-5-YL)-3-(2-FLUORO-5-(HYDROXYMETHYL)PYRIDIN-4-YL)UREA BRM/BRG1 ATP Inhibitor-1 | 2270879-17-7 | 10 mM * 1 mL in DMSO | 3960元 |