227321-12-2
中文名稱
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
英文名稱
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
CAS
227321-12-2
分子式
C25H29N3O2S
分子量
435.58
MOL 文件
227321-12-2.mol
更新日期
2026/06/12 17:40:20
227321-12-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T26221 英文別名
SR 13800MCT1-IN-2
MCT-1-IN-2,MCT1 IN 2,MCT1IN2
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
物理化學(xué)性質(zhì)
熔點(diǎn)152 °C
沸點(diǎn)642.8±65.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)14.87±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
MCT1-IN-2 是有效的單羧酸鹽轉(zhuǎn)運(yùn)蛋白 1 (MCT1) 抑制劑。MCT1-IN-2 具有抗癌活性。體外研究
MCT1-IN-2 (compound 3) has a pK
i
of 9.48 for Jurkat T-cells and inhibits human peripheral blood mononuclear cells (PBMC) proliferation (pIC
50
=8.61).
MCT1-IN-2 (compound 1) has an EC
50
of 5.5 nM (MTT assay) and an IC
50
of 105 nM (lactate transport inhibition assay) in human Raji lymphoma cell proliferation.