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2320261-63-8

物理化學(xué)性質(zhì)

溶解度Ethanol: 0.3 mg/ml; PBS (pH 7.2): 2.5 mg/ml
形態(tài)A crystalline solid

應(yīng)用領(lǐng)域

用途一
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.

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概述
NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) 是一種具有口服活性的胰島素樣生長(zhǎng)因子1受體 (IGF-1R) 的抑制劑,IC50 值為 0.15 μM。NVP-AEW541 dihydrochloride 也抑制 InsR,IC50 值為 0.14 μM。NVP-AEW541 dihydrochloride 具有抗腫瘤活性。
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