2351104-40-8
2351104-40-8 結(jié)構(gòu)式
基本信息
英文別名
RXFP3/4 agonist 1Hydrazinecarboximidamide, N-[2-(4-chlorophenyl)ethyl]-2-[(7-ethyl-5-hydroxy-1H-indol-3-yl)methylene]-
物理化學(xué)性質(zhì)
沸點(diǎn)605.1±65.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)17.56±0.30(Predicted)
常見問(wèn)題列表
生物活性
RXFP3/4 agonist 1 是一種松弛素家族肽 3/4 受體 (RXFP3/4) 抑制劑，EC50 值分別為 82 和 2 nM。能夠增強(qiáng)大鼠的食物攝取量。靶點(diǎn)
EC50: 82 nM (RXFP3), 2 nM (RXFP4)
體外研究
RXFP3/4 agonist 1 (Compound 4) inhibits orskolin-stimulated cAMP accumulation in CHO-K1 cells stably overexpressing RXFP3 and RXFP4, with EC 50 s of 12.8 and 1.6?nM, respectively.