23567-97-7
中文名稱
8-BROMO-ATP
英文名稱
8-bromoadenosine 5'-triphosphate
CAS
23567-97-7
分子式
C10H15BrN5O13P3
分子量
586.08
MOL 文件
23567-97-7.mol
23567-97-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)983.1±75.0 °C(Predicted)
密度2.85±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)0.97±0.50(Predicted)
常見問題列表
生物活性
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate)，一種 ATP 類似物，是一種嘌呤能 P2X receptor 受體的激動劑。8-Bromo-ATP 對多發(fā)性骨髓瘤細(xì)胞具有細(xì)胞毒性，IC50 為 23.1 μM。體外研究
8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma.
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations.
Cell Viability Assay
| Cell Line: | MM 1.s cells |
| Concentration: | 10 μM, 20 μM, 30 μM, 40 μM, 50 μM |
| Incubation Time: | 5 days |
| Result: | Showed cytotoxic to multiple myeloma. |