2376255-48-8
2376255-48-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-111675 | AC-FLTD-CMK Ac-FLTD-CMK | 2376255-48-8 | 1 mg | 3700元 |
| 2026/06/05 | HY-111675 | AC-FLTD-CMK Ac-FLTD-CMK | 2376255-48-8 | 10 mM * 1 mL in DMSO | 10564元 |
常見問題列表
|
Caspase-1 46.7 nM (IC 50 ) |
Caspase-4 1.49 μM (IC 50 ) |
Caspase-5 329 nM (IC 50 ) |
Caspase-11
|
Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.