2378114-72-6
中文名稱
LANREOTIDE ACETATE
英文名稱
Lanreotide acetate
CAS
2378114-72-6
分子式
C56H73N11O12S2
分子量
1156.39
MOL 文件
2378114-72-6.mol
更新日期
2026/07/11 10:08:47
2378114-72-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
形態(tài)Solid
顏色White to off-white
序列{d-2nal}-Cys-Tyr-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)
醋酸蘭瑞肽價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/07/06 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 5mg | 892.93元 |
| 2026/07/06 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 25mg | 2678.21元 |
| 2026/06/05 | HY-P1959A | 醋酸蘭瑞肽 Lanreotide acetate | 2378114-72-6 | 1 mg | 300元 |
常見問題列表
生物活性
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate 是一種天然生長(zhǎng)抑素肽的類似物，是生長(zhǎng)激素 growth hormone (GH)的生理抑制劑。Lanreotide 也具有抗腫瘤作用。體外研究
Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100? nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion.
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000?nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57?nM.
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro.
體內(nèi)研究
Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition.
| Animal Model: | Male nude mice, 8 weeks old and 20–25?g in body weight (GH3 tumor-bearing nude mice) |
| Dosage: | 2.5, 5, 10?mg/kg |
| Administration: | Subcutaneous; daily for 5 days |
| Result: | Produced tumor growth inhibition. |