2387510-80-5
中文名稱
化合物 MRK-740
英文名稱
1,4,9-Triazaspiro[5.5]undecane, 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methyl-4-pyridinyl)-
CAS
2387510-80-5
分子式
C25H32N6O3
分子量
464.56
MOL 文件
2387510-80-5.mol
更新日期
2026/05/28 12:24:09
2387510-80-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 MRK-740 英文別名
1,4,9-Triazaspiro[5.5]undecane, 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methyl-4-pyridinyl)-物理化學(xué)性質(zhì)
沸點(diǎn)654.9±65.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
酸度系數(shù)(pKa)11.65±0.10(Predicted)
形態(tài)Solid
顏色White to yellow
應(yīng)用領(lǐng)域
用途一
MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor. It is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4.