2387510-84-9
2387510-84-9 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點562.7±50.0 °C(Predicted)
密度1.864±0.06 g/cm3(Predicted)
溶解度Soluble to 100 mM in DMSO and to 50 mM in ethanol
酸度系數(shù)(pKa)6.28±0.40(Predicted)
常見問題列表
生物活性
AM12 抑制鑭系元素誘發(fā)的 TRPC5 活性，IC50 為 0.28 μM。靶點
IC50: 0.28 μM (TRPC5)
體外研究
AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A.
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it.
AM12 also inhibits Ca
2+
entry evoked by Gd
3+
. AM12 inhibits the Gd
3+
-evoked Ca
2+
signal with an IC
50
of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd
3+
-evoked signal.