2415263-04-4
2415263-04-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)702.0±70.0 °C(Predicted)
密度1.25±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)9.25±0.28(Predicted)
常見問題列表
生物活性
TP-238 是一種有效的選擇性的 CECR2/BPTF 雙探針，pIC50 值分別為 7.5 和 6.5。TP-238 還抑制 BRD9，pIC50 為 5.9，對(duì)其他 338 種激酶的活性較低。靶點(diǎn)
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CECR2 7.5 (pIC 50 ) |
BPTF 6.5 (pIC 50 ) |
BRD9 5.9 (pIC 50 ) |
體外研究
TP-238 (compound 4) has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 shows an IC 50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay. ITC shows TP-238 with a K d of 10 nM for CECR2 and 120 nM for BPTF.