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2426685-25-6

中文名稱 2426685-25-6
英文名稱 L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-
CAS 2426685-25-6
分子式 C107H150N34O32S2
分子量 2488.7
MOL 文件 2426685-25-6.mol
2426685-25-6 結構式 2426685-25-6 結構式

基本信息

英文別名
L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-

物理化學性質(zhì)

密度1.60±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
TPP-1 是 PD-1/PD-L1 相互作用的有效抑制劑。TPP-1 與 PD-L1 特異性高親和力結合 (KD=95 nM)。動物模型中，TPP-1 通過再激活 T 細胞功能抑制腫瘤生長。
體外研究

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction.?The?K D value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1.TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation.

體內(nèi)研究

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors.

Animal Model: 5 to 6-week-old female Balb/c nude mice? injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result: Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.
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