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243966-09-8

中文名稱 TCS 401
英文名稱 TCS 401
CAS 243966-09-8
分子式 C10H11ClN2O5S
分子量 306.72
MOL 文件 243966-09-8.mol
更新日期 2026/05/22 12:33:43
243966-09-8 結(jié)構(gòu)式 243966-09-8 結(jié)構(gòu)式

基本信息

中文別名
TCS 401鹽酸鹽
英文別名
TCS 401 HCl
TCS-401
TCS401
TCS-401 Hydrochloride

物理化學(xué)性質(zhì)

儲存條件Inert atmosphere,2-8°C
儲存條件under inert gas (nitrogen or Argon) at 2-8°C
溶解度0.1 M NaOH: 5 mg/ml
形態(tài)結(jié)晶固體
顏色Light yellow to khaki
InChIKeyLQGCAMWQDSYOAY-UHFFFAOYSA-N
SMILES[s]1c2c(c(c1NC(=O)C(=O)O)C(=O)O)CC[N+H2]C2.[Cl-]

安全數(shù)據(jù)

WGK GermanyWGK 3
存儲類別11 - Combustible Solids

圖譜信息

常見問題列表

生物活性
TCS 401 是選擇性的蛋白酪氨酸磷酸酶 1B (protein tyrosine phosphatase 1B) 抑制劑。
體外研究

TCS-401 (0.5, 1, 2?μM) significantly increases the proliferation of RPE cells. TCS-401 significantly increases the expression of cyclin A and cyclin D1 at the concentrations of 1 and 2 μM in a concentration-dependent manner. TCS-401 at concentrations of 0.5, 1, and 2 μM significantly increases phosphorylation of Erk and Akt compared to the control group. The activation of Erk and Akt by TCS-401 is blocked by pretreatment with PD98059 and LY294002, respectively. CS-401 treatment activates the MEK/Erk and PI3K/Akt signaling pathways and induces proliferation, differentiation, and migration in RPE cells. CS-401 dose dependently inhibits the RPTC-Sup-induced reduction of fibronectin and α-SMA. At 1 μM, TCS-401 reverses the levels of fibronectin and α-SMA about onefold and at a dose of 2 μM, TCS-401 brings back fibronectin and α-SMA expression to near normal levels.

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