2446154-91-0
中文名稱
化合物 T10607
英文名稱
[1,?1'-?Biphenyl]?-?4-?carboxamide, N-?[(3R,?6R,?7R)?-?3,?4,?5,?6,?7,?8,?9,?10-?octahydro-?7-?methoxy-?3,?6,?9-?trimethyl-?10-?oxo-?2H-?1,?4,?9-?benzoxadiazacyclodod?ecin-?12-?yl]?-?, rel-
CAS
2446154-91-0
分子式
C30H35N3O4
分子量
501.62
MOL 文件
2446154-91-0.mol
2446154-91-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)626.0±55.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.41±0.70(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
BRD5631 是一種自噬 (autophagy) 增強(qiáng)劑，通過(guò)與 mTOR 無(wú)關(guān)的通路來(lái)增強(qiáng)自噬。BRD5631 能夠影響先前與自噬相關(guān)的幾種細(xì)胞疾病表型，包括蛋白聚集、細(xì)胞存活、細(xì)菌復(fù)制和炎性因子的產(chǎn)生。靶點(diǎn)
Autophagy
體外研究
BRD5631 (10 μM, 48 hours) leads to increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay.
BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner.
Cell Viability Assay
| Cell Line: | HeLa cells. |
| Concentration: | 10 μM. |
| Incubation Time: | 48 hours. |
| Result: | Led to increased levels of LC3-II. |