2639638-66-5
中文名稱
BAY-069
英文名稱
INDEX NAME NOT YET ASSIGNED
CAS
2639638-66-5
分子式
C22H14ClF3N2O3
分子量
446.81
MOL 文件
2639638-66-5.mol
2639638-66-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.450±0.06 g/cm3(Predicted)
溶解度DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml
酸度系數(shù)(pKa)6.02±0.40(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
BAY-069 is a BCAT1/2 Inhibitor and Chemical Probe. BAY-069 displays high cellular activity and very good selectivity. BAY-069 displays high cellular activity. Its overall in vivo pharmacokinetic profile and its selectivity in various in vitro panels suggest that BAY-069 is suitable for in vivo experiments. Note: BAY-069 is the more active atropisomer with M-helical with IC50 of 31 nM (BCAT1), while the other atropisomer has only micromolar activity. BAY-771 is the negative control for BAY-609.常見問(wèn)題列表
概述
BAY-069 是一種有效的支鏈氨基酸轉(zhuǎn)氨酶 1 和 2 (BCAT1, BCAT2) 抑制劑，IC50 分別為 31 nM 和 153 nM。BAY-069 也可以用作化學(xué)探針。BAY-069 可用于抗癌研究。