2735720-80-4
英文名稱
1,4-Benzodioxin-5-carboxamide, 2,3-dihydro-7-[5-(4-morpholinyl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-(3-pyridinylmethyl)-
CAS
2735720-80-4
分子式
C26H23N3O6S
分子量
505.54
MOL 文件
2735720-80-4.mol
2735720-80-4 結(jié)構(gòu)式
基本信息
英文別名
1,4-Benzodioxin-5-carboxamide, 2,3-dihydro-7-[5-(4-morpholinyl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-(3-pyridinylmethyl)-應(yīng)用領(lǐng)域
用途一
SRX3212 is a Novel BRD4/PI3Kα inhibitor, displaying an IC50 of 3.7 nM toward BRD4BD1 and 32 nM toward BRD4BD2, and therefore was~65-fold more potent inhibitor of BRD4BD1 and~48-fold more potent inhibitor of BRD4BD2 than SF2523 (GLXC-10641), retaining its high inhibitory activity for PI3Kα (IC50: 22 nM).