2750001-23-9
中文名稱
AZD0095
英文名稱
INDEX NAME NOT YET ASSIGNED
CAS
2750001-23-9
分子式
C27H32N8O2
分子量
500.6
MOL 文件
2750001-23-9.mol
更新日期
2026/05/28 12:24:09
2750001-23-9 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.38±0.1 g/cm3(Predicted)
溶解度DMSO: Sparingly soluble: 1-10 mg/ml
酸度系數(shù)(pKa)5.33±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
InChIKeyPHDAGSZQGNWGFE-FKEMPHOKNA-N
SMILESCC1=C(C(C)=NC2=NC(C)=NN12)O[C@@H]1CCN(C2C=CC(C3N=NC(CN4CCOCC4)=CC=3)=CC=2)C1 |&1:13,r|
應(yīng)用領(lǐng)域
用途一
AZD0095 is a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. AZD0095 has excellent potency (1.3 nM), MCT1 selectivity (>1000×), secondary pharmacology, clean mechanism of action, suitable properties for oral administration in the clinic, and good preclinical efficacy in combination with cediranib.