2756173-91-6
中文名稱
化合物 CHNQD-01255
英文名稱
Carbonic acid, (1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-decahydro-1-hydroxy-6-methyl-4-oxo-4H-cyclopent[f]oxacyclotridecin-13-yl 3-pyridinylmethyl ester
CAS
2756173-91-6
分子式
C23H29NO6
分子量
415.48
MOL 文件
2756173-91-6.mol
2756173-91-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 CHNQD-01255 英文別名
Carbonic acid, (1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-decahydro-1-hydroxy-6-methyl-4-oxo-4H-cyclopent[f]oxacyclotridecin-13-yl 3-pyridinylmethyl ester物理化學(xué)性質(zhì)
沸點(diǎn)648.4±55.0 °C(Predicted)
密度1.22±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.76±0.60(Predicted)
應(yīng)用領(lǐng)域
用途一
CHNQD-01255 significantly suppressed tumor growth (TGI = 61.0%) at a dose of 45 mg/kg (p.o.) in the xenograft model. Notably, the improved safety profile of CHNQD-01255 (MTD > 750 mg/kg, p.o.) was confirmed to be superior to that of BFA (MTD < 506 mg/kg). Overall, CHNQD-01255 may serve as a safe and effective new anti-HCC prodrug.