2765218-56-0
中文名稱
5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE
英文名稱
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-
CAS
2765218-56-0
分子式
C16H15N3O2S
分子量
313.37
MOL 文件
2765218-56-0.mol
更新日期
2026/05/12 17:33:31
2765218-56-0 結(jié)構(gòu)式
基本信息
中文別名
5-苯基-N-[3-(2-噻唑基)丙基]異噁唑-3-甲酰胺5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE
英文別名
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-物理化學(xué)性質(zhì)
沸點(diǎn)559.1±45.0 °C(Predicted)
密度1.266±0.06 g/cm3(Predicted)
儲(chǔ)存條件-10 to -25°C
溶解度DMSO: 2mg/mL, clear
酸度系數(shù)(pKa)13.06±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP.常見問題列表
概述
PY-60 是一種靶向膜聯(lián)蛋白A2 (ANXA2) 的 YAP 轉(zhuǎn)錄活性的特異的激活劑 (Kd=1.4 μM)。PY-60 直接與 ANXA2 結(jié)合并拮抗其抑制 YAP 活性的正常細(xì)胞功能。5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-141644 | 5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE PY-60 | 2765218-56-0 | 5 mg | 990元 |
| 2026/06/05 | HY-141644 | 5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE PY-60 | 2765218-56-0 | 10 mM * 1 mL in DMSO | 1089元 |
| 2026/06/05 | HY-141644 | 5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE PY-60 | 2765218-56-0 | 10 mg | 1585元 |