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280783-56-4

中文名稱 Ro 64-6198
英文名稱 Ro 64-6198
CAS 280783-56-4
分子式 C26H31N3O
分子量 401.54
MOL 文件 280783-56-4.mol
280783-56-4 結構式 280783-56-4 結構式

基本信息

中文別名
化合物 T16772
英文別名
Ro 64-6198
Ro 64-6198 >=98% (HPLC)
1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-

物理化學性質

沸點626.2±55.0 °C(Predicted)
密度1.25±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(pKa)15.03±0.20(Predicted)
形態(tài)Solid
顏色White to yellow
Ro 64-6198價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2026/06/05HY-12844Ro 64-6198
Ro 64-6198
280783-56-41mg900元
2026/06/05HY-12844Ro 64-6198
Ro 64-6198
280783-56-45mg2160元
2026/06/05HY-12844Ro 64-6198
Ro 64-6198
280783-56-410mM * 1mLin DMSO2376元

常見問題列表

生物活性
Ro 64-6198 是一種有效的,選擇性的,非肽,高親和力,高細胞通透性和腦滲透 N/OFQ 受體 (NOP) 激動劑,EC50 值為 25.6 nM。Ro 64-6198 對 NOP 受體的選擇性至少是經典阿片受體的 100 倍。Ro 64-6198 可用于壓力和焦慮,成癮,神經性疼痛,咳嗽和厭食癥的研究。
靶點

Nociceptin receptor

體外研究

Ro 64-6198 also produces rapid desensitization of the NOP receptor. In vitro studies shows that treatment with Ro 64-6198 results in a functional desensitization of the receptor, a loss in binding sites, and an apparent decrease in binding affinity. The desensitization produced by Ro 64-6198 is not reversed by acidic washes.
Ro 64-6198 does recruit both arrestin3 ( EC 50 of 0.912 μM) and arrestin2 ( EC 50 of 1.20 μM) to the NOP receptor in a concentration-dependent manner comparably with N/OFQ.

體內研究

At low doses Ro 64-6198 is anxiolytic in several neophobic tests, including the marble burying test in mice, the elevated plus maze in rats and the open field test in rats. In the marble burying test, at 1 mg/kg, i.p., Ro 64-6198 produces a decrease in the number of marbles buried, without altering locomotor activity, indicating a decrease in neophobia and anxiety. Ro 64-6198 selectively increases the number of open arm transitions and time spent in the open arms of the elevated plus maze at doses of 0.32-3 mg/kg, i.p., without affecting closed arm transitions or locomotor activity in the closed arms. In the open field test, Ro 64-6198, at doses of 0.32-3 mg/kg, attenuates the inhibition of exploration that results from the stress of a novel environment.

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