2889-31-8
2889-31-8 結構式
基本信息
英文別名
C026302-hydroxyglutarate
α-Hydroxyglutaric Acid
alpha-hydroxyglutarate
a-Hydroxyglutaric Acid
2,3-Dideoxypentaric Acid
DL-2-Hydroxyglutaric Acid
物理化學性質
熔點98-100 °C(Solv: ethyl acetate (141-78-6))
沸點394.2±27.0 °C(Predicted)
密度1.508±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
酸度系數(shù)(pKa)3.67±0.10(Predicted)
形態(tài)Liquid
顏色Colorless to light yellow
常見問題列表
生物活性
α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羥基酸形式。α-Hydroxyglutaric acid 是多種 α-酮戊二酸依賴性雙加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羥化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的競爭性抑制劑。體外研究
Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively.
α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases.
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin.