29070-92-6
29070-92-6 結(jié)構(gòu)式
基本信息
茯靈酸
茯苓酸對照品,
茯苓酸?, BR
茯苓酸(茯靈酸)
茯苓酸(標(biāo)準(zhǔn)品)
AKT和ERK信號傳導(dǎo)途徑抑制劑(PACHYMIC ACID)
Pachymicaci
PACHYMIC ACID
Pachymic acid, BR
3-ACETYLTUMULOSIC ACID
24-methylene-,(3β,16α)-
3-O-Acetyltumulosic acid
Poria Extract 29070-92-6
stock Pachymic acid 29070-92-6
Pachymic acid (3-O-Acetyltumulosic acid)
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
藥理藥效:對肝臟具細(xì)胞毒作用，能競爭性抑制磷脂酶A2（phospholipase A2，PLA2）的生物活性，降低PLA2介導(dǎo)的細(xì)胞損傷。
常見問題列表
閃點(diǎn)：184.7ºC
密度： 1.1 g/cm3
沸點(diǎn)：612.2ºC at 760 mmHg
折射率：1.539
蒸汽壓：1.51E-17mmHg at 25°C
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Akt
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ERK
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Pachymic acid (PA) is able to inhibit gallbladder cancer tumorigenesis involving affection of Akt and ERK signaling pathways. Pachymic acid (PA) treatment significantly inhibits Rho A, Akt and ERK pathway in gallbladder carcinoma cells. Pachymic acid (PA) treatment can dose-dependently downregulate PCNA, ICAM-1, RhoA, p-Akt and pERK. Cell growth is inhibited by 10 μg/mL Pachymic acid (PA) 12 h after treatment, and a concentration of 30 μg/mL further reduced cell growth. The growth of cells is suppressed in a time- and dose-dependent manner. After 48 h treatment, about 25%, 40% and 70% of the cell growth are inhibited by Pachymic acid (PA) at concentration of 10 μg/mL, 20 μg/mL and 30 μg/mL, respectively. Pachymic acid (PA) also inhibits the growth of gallbladder carcinoma cells in a time-dependent and dose-dependent manner.
To evaluate the anti-tumor activity of Pachymic acid (PA) in vivo, human lung cancer NCI-H23 tumor xenograft models are used. Pachymic acid (PA) significantly suppresses tumor growth at doses of 30 and 60 mg/kg for 21 days compared with the control group.