290814-68-5
290814-68-5 結(jié)構(gòu)式
基本信息
化合物 T16436
化合物PBOX 6,10 MM DMSO 溶液
6-(萘-1-基)苯并[B]吡咯并[1,2-D][1,4]氧氮雜卓-7-基 二甲基氨基甲酸酯
PBOX-6 >=98% (HPLC)
Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7-yl ester
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-U00446 | PBOX 6 PBOX 6 | 290814-68-5 | 5mg | 1600元 |
| 2025/12/22 | HY-U00446 | PBOX 6 | 290814-68-5 | 10 mM * 1 mLin DMSO | 1760元 |
| 2025/12/22 | HY-U00446 | PBOX 6 PBOX 6 | 290814-68-5 | 10mg | 2050元 |
常見問題列表
Apoptosis, Microtubule
PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells. PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells.