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298708-81-3

中文名稱 298708-81-3
英文名稱 Bay 41-4109
CAS 298708-81-3
分子式 C18H13ClF3N3O2
分子量 395.76
MOL 文件 298708-81-3.mol
更新日期 2024/11/15 18:20:30
298708-81-3 結構式 298708-81-3 結構式

基本信息

中文別名
化合物 T10480L
英文別名
Bay 41-4109
Bayer 41-4109
BAY41-4109
BAY-41-4109
BAYER 41-4109
methyl (R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-

物理化學性質

沸點475.3±45.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 100 mg/mL (252.68 mM);Water : < 0.1 mg/mL (insoluble)
酸度系數(pKa)5.43±0.60(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
298708-81-3價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2025/12/22HY-100029298708-81-3
Bay 41-4109
298708-81-35mg940元
2025/12/22HY-100029298708-81-3
Bay 41-4109
298708-81-310 mM * 1 mLin DMSO1034元
2025/12/22HY-100029298708-81-3
Bay 41-4109
298708-81-310mg1500元

常見問題列表

生物活性
BAY 41-4109是人乙型肝炎病毒 (HBV) 的有效抑制劑,IC50值為 53 nM。
靶點

IC50&Target: 53 nM (HBV)

體外研究

BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro . Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC 50 s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.

體內研究

BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.

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