317326-90-2

中文名稱 HLI 98C; HL98C

英文名稱 HLI 98C

CAS 317326-90-2

分子式 C17H9ClN4O4

分子量 368.73

MOL 文件 317326-90-2.mol

317326-90-2 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域常見問題列表

基本信息

中文別名

化合物 T27546

英文別名

HL98C
HLI 98C
HLI 98C
HL98C
10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione

物理化學(xué)性質(zhì)

熔點(diǎn)368-369 °C(Solv: water (7732-18-5))

密度1.66±0.1 g/cm3(Predicted)

酸度系數(shù)(pKa)4.71±0.20(Predicted)

應(yīng)用領(lǐng)域

用途一

HLI98C is a HDM2 ubiquitin ligase inhibitor. HLI98C exhibits cytotoxic activities and HDM2 E3 ligase inhibitory activities. In cells, HLI98C allows the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis. The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. HLI98C may demonstrate anti-tumor activity by inhibiting recognition of the E3 enzyme and substrate.

常見問題列表

概述

HLI98C 是一種泛素連接酶抑制劑。HLI98C 抑制 p53 泛素化。HLI98C 抑制 HDM2 自泛素化。