317326-90-2
317326-90-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27546 英文別名
HL98CHLI 98C
HLI 98C
HL98C
10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
物理化學(xué)性質(zhì)
熔點(diǎn)368-369 °C(Solv: water (7732-18-5))
密度1.66±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)4.71±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
HLI98C is a HDM2 ubiquitin ligase inhibitor. HLI98C exhibits cytotoxic activities and HDM2 E3 ligase inhibitory activities. In cells, HLI98C allows the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis. The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. HLI98C may demonstrate anti-tumor activity by inhibiting recognition of the E3 enzyme and substrate.