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32908-73-9

中文名稱(chēng) MAST CELL DEGRANULATING PEPTIDE
英文名稱(chēng) MAST CELL DEGRANULATING PEPTIDE
CAS 32908-73-9
分子式 C110H192N40O24S4
分子量 2587.24
MOL 文件 32908-73-9.mol
更新日期 2026/07/07 17:20:43
32908-73-9 結(jié)構(gòu)式 32908-73-9 結(jié)構(gòu)式

基本信息

中文別名
MCD 肽
肥大細(xì)胞脫粒肽
蜜蜂肥大細(xì)胞脫粒肽
英文別名
MCD
isulfide)
MCD PEPTIDE
Peptide 401
IKCNCKRHVIKPHICRKICGKN-NH2
MCD PEPTIDE (APIS MELLIFERA)
MAST CELL DEGRANULATING PEPTIDE
MAST CELL DEGRANULATING (MCD) PEPTIDE
mastcelldegranulatingpeptide(honeybee)
MCD-PEPTIDE (HONEYBEE, APIS MELLIFERA)
所屬類(lèi)別
生物化工:動(dòng)物提取物

物理化學(xué)性質(zhì)

密度1.50±0.1 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度Soluble in DMSO
形態(tài)Solid
顏色White to off-white
序列Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

安全數(shù)據(jù)

WGK Germany3
RTECS號(hào)OQ5980000
肥大細(xì)胞脫粒肽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2026/06/05HY-12537MAST CELL DEGRANULATING PEPTIDE
Peptide 401
32908-73-91mg930元
2026/06/05HY-12537MAST CELL DEGRANULATING PEPTIDE
Peptide 401
32908-73-95mg3150元
2026/06/05HY-12537Peptide 40132908-73-910 mg5050元

常見(jiàn)問(wèn)題列表

生物活性
Peptide 401 是一種有效的來(lái)源于蜂毒中的肥大細(xì)胞脫顆粒肽,抑制血管通透性。
靶點(diǎn)

serotonin

Histamine Receptor

體內(nèi)研究

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents.

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