3316-02-7
3316-02-7 結(jié)構(gòu)式
基本信息
NSC37044
ZETA-STAT
ζ-Stat (ZETA-STAT)
6-naphthalenetrisulfonicacid,8-hydroxy-3
3,6-Naphthalenetrisulfonicacid,8-hydroxy-1
8-hydroxy-1,3,6-naphthalenetrisulfonic acid
8-hydroxynaphthalene-1,3,6-trisulfonic acid
8-hydroxynaphthalene-1,3,6-trisulphonic acid
1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-123979 | 8-羥基-1,3,6-萘三磺酸 ζ-Stat | 3316-02-7 | 1 mg | 1200元 |
| 2025/12/22 | HY-123979 | 8-羥基-1,3,6-萘三磺酸 ζ-Stat | 3316-02-7 | 5mg | 3000元 |
| 2025/12/22 | HY-123979 | 8-羥基-1,3,6-萘三磺酸 ζ-Stat | 3316-02-7 | 10mg | 4800元 |
常見問題列表
|
aPKC-ζ 5 μM (IC 50 ) |
ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level.
ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations.
ζ-Stat (7 or 10 μM; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%.
ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells.
ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells.
Cell Proliferation Assay
| Cell Line: | MEL-F-NEO, SK-MEL-2 and MeWo cells |
| Concentration: | 0.1, 0.5, 1, 2.5, 5, 7.5, 10 μM |
| Incubation Time: | 3 days |
| Result: |
Decreased proliferation by 47.7% for 5 μM in SK-MEL-2 cells and by 50.6% for 5 μM in MeWo cells.
Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM. |
Western Blot Analysis
| Cell Line: | SK-MEL-2 and MeWo cells |
| Concentration: | 5 μM |
| Incubation Time: | 3 days |
| Result: | Decreased phosphorylated and total PKC-ζ levels. |