331830-20-7
331830-20-7 結(jié)構(gòu)式
基本信息
1,4-DPCA化學(xué)試劑
化合物1,4-DPCA,10 MM DMSO 溶液
4-氧代-4,4-二氫-1,10-菲咯啉-3-羧酸
4-氧代-1,4-二氫-[1,10]鄰二氮雜菲-3-羧酸
1,4-DPCA
TVBAVFFTADCWKG-UHFFFAOYSA-N
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-121172 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 1,4-DPCA | 331830-20-7 | 5mg | 600元 |
| 2025/12/22 | HY-121172 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 1,4-DPCA | 331830-20-7 | 10mM * 1mLin DMSO | 660元 |
| 2025/12/22 | HY-121172 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 1,4-DPCA | 331830-20-7 | 10mg | 950元 |
常見(jiàn)問(wèn)題列表
IC50: 2.4 μM (Collagen hydroxylation); 60 μM (Factor inhibiting HIF (FIH))
1,4-DPCA (24 hours) treatment specifically increases the expression of multiple target genes, including the proangiogenic target genes Vegfa and Hmox1 and proglycolytic targets Ldh-a, Pgk1, Pdk1, and Glut1 in mouse B6 cells.
1,4-DPCA treatment significantly reduces the colony sizes of T4-2 (10 μM 1,4-DPCA) and ZR-75-1 cells (20 μM 1,4-DPCA). 1,4-DPCA-treated T4-2 cells form polarized spheroids in 3D culture. 1,4-DPCA treatment significantly reduces invasive branches in DA-MB-157 (20 μM 1,4-DPCA) and MDA-MB-231 (10 μM 1,4-DPCA) cells.1,4-DPCA inhibits the proliferation of T4-2, ZR-75-1, MDA-MB-157 and MDA-MB-231 cells.
1,4-DPCA treatment suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) (PLGA) discs implanted in the peritoneal cavity for 28 days in mice. 1,4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc, and also limited connective tissue ingrowth, but not to the extent of glucocorticoid inhibition.