34433-31-3
中文名稱
ASOXIME CHLORIDE
英文名稱
ASOXIME CHLORIDE
CAS
34433-31-3
分子式
C14H16Cl2N4O3
分子量
359.21
MOL 文件
34433-31-3.mol
更新日期
2026/07/23 17:37:11
34433-31-3 結(jié)構(gòu)式
基本信息
中文別名
氯化阿索肟化合物 T14333
化合物ASOXIME DICHLORIDE
英文別名
hi6hj6
hi-6
wr249655
Transant
Ccris 7699
HI 6 Chloride
hi-6dichloride
ASOXIME CHLORIDE
pyridinium,4’-carbamoyl-2-formyl-1,1’-(oxydimethylene)di-,dichloride,2-oxi
物理化學(xué)性質(zhì)
熔點(diǎn)145-147°C
儲(chǔ)存條件-20°C冷凍
溶解度在水中的溶解度為15mg/mL（澄清溶液）
形態(tài)粉末
顏色白色至米色
水溶解性H2O: 15mg/mL (clear solution)
穩(wěn)定性1-10%水溶液
InChI1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H
InChIKeyQELSIJXWEROXOE-UHFFFAOYSA-N
SMILES[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1
常見(jiàn)問(wèn)題列表
生物活性
Asoxime dichloride 是乙酰膽堿受體 (AChRs) 拮抗劑，包括煙堿受體，α7 乙酰膽堿受體。Asoxime dichloride 參與調(diào)節(jié)免疫應(yīng)答。Asoxime dichloride 可作為抗原使用，改善神經(jīng)系統(tǒng)的免疫效果。靶點(diǎn)
IC50: acetylcholine receptors (AChRs)
體內(nèi)研究
Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1?mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant.
| Animal Model: | Balb/c mice |
| Dosage: | 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg |
| Administration: | Intramuscular injection into the rear limb |
| Result: | Improved vaccination efficacy at the level of immunity regulation by the nervous system. |