3469-78-1
中文名稱
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid
英文名稱
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid
CAS
3469-78-1
分子式
C11H18N5O12P3
分子量
505.21
MOL 文件
3469-78-1.mol
3469-78-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13547 英文別名
AMP-P(CH2)PAMP PCP,AMPPCP
Einecs 222-435-7
β,γ-MethyleneATP
β,γ-Methylene ATP
Adenylyl methylenediphosphonate
5'-adenylyl (beta,gamma-methylene)diphosphonate
5'-Adenylic acid (phosphonomethyl)phosphonyl ester
5'-Adenylic acid, monohydride with methylenebis(phosphonic acid)
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid
物理化學(xué)性質(zhì)
沸點(diǎn)968.2±75.0 °C(Predicted)
密度2.50±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)0.68±0.10(Predicted)
常見問題列表
生物活性
AMP-PCP 是一種 ATP 類似物，可以以 Kd 值 為 3.8 μM 來結(jié)合到 Hsp90 的 N 末端結(jié)構(gòu)域。AMP-PCP 結(jié)合有利于 Hsp90 活性同型二聚體的形成。靶點(diǎn)
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HSP90 3.8 μM (Kd) |
體外研究
AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.