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35409-55-3

英文名稱 (2S,7R,11S)-2,11-diamino-6-[(4S)-4-amino-4-carboxy-butanoyl]-7-[[(4S)-4-amino-4-carboxy-butanoyl]-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]-7-[(4S)-4-amino-4-carboxy-butanoyl]oxycarbonyl-6-(carboxymethyl)-5,8-dioxo-dodecanedioic acid
CAS 35409-55-3
分子式 C44H54N12O21
MOL 文件 35409-55-3.mol
35409-55-3 結(jié)構(gòu)式 35409-55-3 結(jié)構(gòu)式

基本信息

英文別名
Pteglu6
Hexaglutamyl folate
hexaglutamate folate
(2S,7R,11S)-2,11-diamino-6-[(4S)-4-amino-4-carboxy-butanoyl]-7-[[(4S)-4-amino-4-carboxy-butanoyl]-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]-7-[(4S)-4-amino-4-carboxy-butanoyl]oxycarbonyl-6-(carboxymethyl)-5,8-dioxo-dodecanedioic acid

應用領(lǐng)域

用途一
is a naturally occurring form of folic acid. The bioavailability of dietary folate may be hampered by the need of the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans leads to anemia, neural tube defects and, possibly, chronic diseases such as cardiovascular disease, colon cancer, and neurocognitive dysfunction. Folate status is ascertained not only by the intake of folate but also by its bioavailability. Bioavailability is defined as the proportion of ingested folate that is absorbed and available for metabolic processes and storage. In humans, the bioavailability of folate from the diet is assumed to be {approx}50%, whereas the bioavailability of synthetic folic acid used in supplements and as a food fortificant is estimated to range from 76% to 97%. Patients with pernicious anemia in relapse and postgastrectomy macrocytic anemia cannot readily utilize for hematopoiesis a naturally occurring conjugate of pteroylglutamic acid although they respond promptly to administration of the free vitamin. This effect varies in different patients. Inability to utilize the conjugated vitamin appears to depend at least in part upon a conjugase-inhibiting substance present in natural sources of conjugate.

常見問題列表

概述
Pteroylhexaglutamate (PteGlu6) 可抑制50% 的 T2 噬菌體誘導的合成酶 (在沒有 Mg2+ 的情況下,濃度為 0.6 μM)。Pteroylhexaglutamate 是蝶酰聚谷氨酸水解酶的底物,可用于監(jiān)測蝶酰聚谷氨酸水解酶的活性。
"35409-55-3" 相關(guān)產(chǎn)品信息
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