3545-67-3
3545-67-3 結(jié)構(gòu)式
基本信息
Unii-nt0J0815S5
Einecs 222-592-1
Aralen hydrochloride
Chloroquine dihydrochloride
4-((4-Amino-1-methylbutyl)amino)-7-chloroquinoline dihydrochloride
Quinoline, 4-((4-amino-1-methylbutyl)amino)-7-chloro-, dihydrochloride
N4-(7-chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine,dihydrochloride
1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, dihydrochloride (9ci)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-17589B | 鹽酸氟西汀雜質(zhì) Chloroquine dihydrochloride | 3545-67-3 | 5 mg | 350元 |
| 2025/12/22 | HY-17589B | 鹽酸氟西汀雜質(zhì) Chloroquine dihydrochloride | 3545-67-3 | 10 mM * 1 mLin DMSO | 385元 |
| 2025/12/22 | HY-17589B | 鹽酸氟西汀雜質(zhì) Chloroquine dihydrochloride | 3545-67-3 | 10 mg | 560元 |
常見問題列表
|
HIV-1
|
Malaria
|
TLRs
|
SARS-COV-2
|
Chloroquine dihydrochloride (20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine dihydrochloride (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells[1]. Chloroquine dihydrochloride (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine dihydrochloride has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression. TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly reduces HuH7 cell proliferation in vitro.
Chloroquine dihydrochloride (0.01-100 μM; 48?hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV-2) at low-micromolar concentration (EC50=1.13?μM). Chloroquine dihydrochloride blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.
Chloroquine dihydrochloride (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model.
TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine.